BIOptimizers - CogniBiotics 60caps

Non-members: $82.95
Members price: $78.80 JOIN TO SAVE ($4.15) 5% Off
Non-members: $82.95
Members price: $78.80 JOIN TO SAVE ($4.15) 5% Off


  • A nootropic blend that improves brain health, mental clarity, learning, memory, and focus by improving the gut bacteria
  • Helps with brain fog and procrastination
  • Promotes relaxation and balanced stress responses
  • Contains 17 nootropic and adaptogenic herbs that boost cognitive function, mood, and stress resilience by improving your gut flora
  • A powerful synergy of 10 brain-friendly probiotic bacteria strains, which have been shown to boost mood and cognitive function
  • Improves the balance of neurotransmitters, including acetylcholine, serotonin, GABA, and dopamine in the brain
  • Improves neuroregeneration and neuroplasticity by improving BDNF and NGF, which boost learning capacity and mood
  • Protects the brain against oxidative stress
  • Improves blood flow to the brain
  • Supports digestive health and regularity

Improves Brain Health Through the Gut-Brain-Microbiome Axis

Your gut feeling is an example of how your gut works with your brain. Recent research[2] shows that gut health and the gut microbiome strongly influence brain health. Your gut bacteria can control your thoughts, emotions, and stress resilience. Also, many people with mental health and neurological disorders have dysbiosis and digestive issues. Often, an improvement in gut bacteria composition in these people improves their mood and brain function.[3]

CogniBiotics contain bacteria strains that are known as mood enhancers, and for their potential to improve and cognitive function. In addition, the Chaihu-Shugan-San herb formula in CogniBiotics works by improving the dysbiosis[4] and digestive issues. However, CogniBiotics is only meant for general brain health and not approved to treat any disease.

Boost BDNF (Brain-Derived Neurotrophic Factor)
Boost low mood, reduce or relief anxiety
Reduce stress
Produce mood-boosting vitamins (e.g. K and B-12)
Rejuvenate your brain and improve brain-gut connection
Generate serotonin and happiness chemicals
Enhance cognitive performance
Promote a Balanced Stress Response and Stress Resilience

Stress can cause anxiety, poor sleep, abnormal appetite, reduced performance, and many other negative health effects. Adaptogens are herbs or substances that help support the nervous system to reduce the stress response, promote calmness, or improve your ability to deal with the stress. CogniBiotics contain several adaptogenic herbs such as Schisandra and Chinese licorice.

Promote Healthy Acetylcholine Levels

Acetylcholine is an important neurotransmitter for learning and memory. P. multiflorum, S. miltiorrhiza, and R. glutinosa in CogniBiotics are cholinergic herbs that increase acetylcholine levels.[5]

Improve Neurotransmitter Balance

In animal studies[6] the probiotics L. plantarum, L. helveticus, L. fermentum, L. rhamnosus, and B. infantis promote the balance of serotonin, dopamine, and GABA in the brain. The good bacteria also help ensure[7] that the used neurotransmitters are not converted into metabolites that may cause anxiety, brain fog, and neurologic disorders.

Improve Brain-Derived Neurotrophic Factor

The good bacteria[8] and herbs[9] in CogniBiotics work together to stimulate the production of proteins that help the brain grow, reorganize, and adapt. These proteins include brain-derived neurotrophic factor (BDNF) and neural growth factor (NGF). Increasing these proteins help with learning, memory, and mood.

Protecting Neurons Against Oxidative Stress

Oxidative stress comes from mental-emotional stress, toxic exposure, inflammation, poor diet, unhealthy lifestyle, and more. Nowadays, most people don’t consume enough antioxidants in their diets. When oxidative stress exceeds your body’s antioxidant capacity, it can damage cells. Oxidative stress can contribute to brain fog, fatigue, and neurologic disorders.

Herbs in CogniBiotics contain antioxidants that can cross the blood-brain barrier and protect your brain from day-to-day oxidative stress.

Increases Blood Flow to the Brain

Your brain needs oxygen and vital nutrients to work well, but it’s also the organ that’s hardest to deliver blood to. It’s located at the highest point in the body and has many tiny blood vessels. Stress, poor blood vessel health, oxidative stress, and low blood pressure can reduce blood flow to the brain. When the brain gets reduced blood flow, it doesn’t get healthy levels of oxygen and nutrients. The deprivation can cause fatigue, brain fog, poor cognitive function, and low mood.

The Chaihu-Shugan-San herb formula normalizes brain blood flow[10] in depression patients.

Producing Beneficial Postbiotics, Such as Butyrate

Postbiotics are produced when your probiotic bacteria ferment the prebiotic fibers, such as the small fatty acids propionate and butyrate.

Low mood, brain fog, and fatigue[11] are caused by sluggish neurons that can’t produce enough energy (ATP). The small fatty acids[12] can enter the brain, energize the sluggish neurons, and lower oxidative stress Your neurons can also burn the fatty acids for energy. Butyrate also boosts BDNF levels.

The small fatty acids also counteract chronic inflammation[13] and strengthen the gut and blood-brain barriers.[14] They also promote a healthy metabolism and blood sugar levels,[15] which are important for brain health.

Most nootropics and adaptogens only target the brain, which leaves out the key pieces of your cognitive function and mental health: your gut and the gut microbiome. CogniBiotics is the only probiotic-nootropic blend on the market that improves the entire gut-brain-microbiota axis.

The formula contains a powerful combination of 17 herbs known to provide mood support and enhance cognitive function by improving the gut microbiome.[1] In addition, the 10 bacteria strains in CogniBiotics work synergistically to boost brain health and promote a balanced stress response.

Formulated by expert Chinese Herbal Scientists
The 2,200-year-old Chaihu-Shugan-San herb blend improves mood, brain health, and happiness through the gut microbiome
10 research-based bacteria strains that synergize to improve mood and cognitive function
Prebiotic complex boosts probiotic survival and effectiveness
Adaptogenic: calming, promotes a balanced-stress response from the nervous system and mitigates negative health effects of stress
Nootropic: boost memory and learning, and maintain healthy brain function amidst stress
Improves mood and happiness
Protects the brain with antioxidants that can enter the brain
Supports neuroplasticity, which improves brain adaptation and healing
Can be taken on an empty stomach or with meals
100% Satisfaction guarantee with respect to quality, purity, potency, and effectiveness
Produced in small batches with medical-grade ingredients.

Proprietary Probiotic Blend (L. casei, L. rhamnosus, B. animalis, B. breve, B. longum, L. reuteri, L. helveticus, L. plantarum, B. infantis, L. fermentum), Prebiotic Complex (Organic Inulin, Xylooligosaccharides), Chinese Herbal Blend (Cristaria plicata, Reynoutria multiflora, Ligustrum lucidum, Salvia miltiorrhiza, Eclipta protrata, Cuscuta chinensis, Albizia julibrissin, Rehmannia glutinosa, Schisandra chinensis, Acorus tatarinowii, Bupleurum chinense, Paeonia lactiflora, Cyperus rotundus, Citrus aurantium, Ligusticum chuanxiong, Glycyrrhiza uralensis, Citrus reticulata

Other Ingredients: L-Leucine, silica, hypromellose (capsule).

When To Take CogniBiotics?

The goal is to deliver the probiotics to your large intestine relatively intact and maximize absorption of the herbs, so you want to minimize their exposure to your stomach acid and digestive enzymes. Your gut secretes digestive enzymes and stomach acid when you have food in your stomach. Therefore, you should take your CogniBiotics on an empty stomach. However, if you get stomach upset from taking it without food or cannot take it without food for any other reasons, it is still beneficial when taken with meals.

Take CogniBiotics first thing in the morning on an empty stomach. Some people also find significant cognitive and mood boosts when they take CogniBiotics before or with lunch and dinner.

Because CogniBiotics contain probiotics, be sure to take it at least an hour away from antibiotics or dietary supplements that have antibacterial properties.

CogniBiotics and Depression

The latest research shows that, aside from life events, the following factors contribute to depression,[16] cognitive dysfunction, and other mental health problems:

Imbalanced gut microbiome
Sluggish neurons in the brain due to mitochondria dysfunction[17]
Overactivated stress response[18]
Increased inflammation[19]
Intestinal permeability[20]
Abnormal circadian rhythm or sleep patterns[21]
A leaky blood-brain barrier[22]
Unstable or poor blood sugar control[23]
Nutrient deficiencies,[24] such as omega-3, B vitamins, minerals, and amino acids
CogniBiotics promotes good mood, mental health, cognitive function, and stress resilience by:

Improving the gut microbiome
Energizing the neurons
Promoting a balanced immune response
Supporting the gut and brain barriers
Promoting digestive health
Supporting blood sugar control (Blood Sugar Breakthrough--- coming soon)